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Haloacid dehydrogenase superfamily
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Haloacid dehydrogenase superfamily : ウィキペディア英語版
Haloacid dehydrogenase superfamily

In molecular biology, the haloacid dehydrogenase superfamily (HAD superfamily) includes phosphatases, phosphonatases, P-type ATPases, beta-phosphoglucomutases, phosphomannomutases, and dehalogenases, which are involved in a variety of cellular processes ranging from amino acid biosynthesis to detoxification.
== Examples ==

A HAD domain is found in several distinct enzymes including:
* Phospholipid-translocating ATPase , a putative lipid-flipping enzyme involved in cold tolerance in ''Arabidopsis''
* 3-deoxy-D-manno-octulosonate (KDO) 8-phosphate phosphatase (), which catalyses the final step in the biosynthesis of KDO - a component of lipopolysaccharide in Gram-negative bacteria
* Mannosyl-3-phosphoglycerate phosphatase (), which hydrolyses mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate
* Phosphoglycolate phosphatase (), which catalyses the dephosphorylation of 2-phosphoglycolate
Human genes encoding proteins that contain this domain include:
* ATP8B3, ATP8B4, ATP10A, ATP10B, ATP10D

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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